{"id":2357,"date":"2026-03-17T13:06:34","date_gmt":"2026-03-17T04:06:34","guid":{"rendered":"https:\/\/www.hamajima.co.jp\/rika\/bio\/?page_id=2357"},"modified":"2026-03-17T13:06:34","modified_gmt":"2026-03-17T04:06:34","slug":"substratespecificity","status":"publish","type":"page","link":"https:\/\/www.hamajima.co.jp\/rika\/bio\/substratespecificity\/","title":{"rendered":"\u3010\u9032\u5316View\u3011\u57fa\u8cea\u7279\u7570\u6027\u306e\u7372\u5f97"},"content":{"rendered":"\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\" style=\"grid-template-columns:20% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"348\" height=\"90\" src=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2022\/09\/web_shinka_View_icon-1.png\" alt=\"\" class=\"wp-image-1169 size-full\" srcset=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2022\/09\/web_shinka_View_icon-1.png 348w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2022\/09\/web_shinka_View_icon-1-300x78.png 300w\" sizes=\"auto, (max-width: 348px) 100vw, 348px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\" style=\"font-size:30px\"><strong>\u57fa\u8cea\u7279\u7570\u6027\u306e\u7372\u5f97<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\" style=\"font-size:25px\"><strong>\u9175\u7d20\u306e\u57fa\u8cea\u7279\u7570\u6027<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u8cea\u7279\u7570\u6027\u3068\u306f\u300c\u9175\u7d20\u306f\u7279\u5b9a\u306e\u57fa\u8cea\u3068\u3057\u304b\u53cd\u5fdc\u3057\u306a\u3044\u300d\u3068\u3044\u3046\u3053\u3068\u3067\uff0c\u9175\u7d20\u3068\u57fa\u8cea\u306f\u300c\u304b\u304e\u3068\u304b\u304e\u7a74\u306e\u95a2\u4fc2\u300d\u306b\u305f\u3068\u3048\u3089\u308c\u308b\u3002\u9175\u7d20\u306f\u6d3b\u6027\u90e8\u4f4d\u3068\u3088\u3070\u308c\u308b\u90e8\u5206\u3067\u57fa\u8cea\u3068\u7d50\u5408\u3057\u3066\uff0c\u9175\u7d20-\u57fa\u8cea\u8907\u5408\u4f53\u3092\u3064\u304f\u3063\u3066\u304b\u3089\u53cd\u5fdc\u304c\u8d77\u3053\u308b\u306e\u3067\uff0c\u9175\u7d20\u306f\u6d3b\u6027\u90e8\u4f4d\u306e\u7acb\u4f53\u69cb\u9020\u306b\u3074\u3063\u305f\u308a\u306f\u307e\u308b\u57fa\u8cea\u3068\u3057\u304b\u53cd\u5fdc\u3057\u306a\u3044\u3053\u3068\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"221\" src=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme1-1024x221.png\" alt=\"\" class=\"wp-image-1800\" srcset=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme1-1024x221.png 1024w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme1-300x65.png 300w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme1-768x166.png 768w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme1-1536x332.png 1536w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme1-2048x443.png 2048w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u521d\u671f\u306e\u751f\u7269\u306e\u9175\u7d20<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\uff0c\u751f\u547d\u8a95\u751f\u5f8c\u306e\u521d\u671f\u306e\u751f\u7269\u304c\u73fe\u5728\u306e\u751f\u7269\u306e\u3088\u3046\u306b\u53b3\u5bc6\u306a\u57fa\u8cea\u7279\u7570\u6027\u3092\u3082\u3064\u9175\u7d20\u3092\u3082\u3063\u3066\u3044\u305f\u3068\u306f\u8003\u3048\u306b\u304f\u3044\u3002\u307e\u305f\uff0c\u907a\u4f1d\u5b50\u306e\u6570\u3082\u591a\u304f\u306a\u304b\u3063\u305f\u306f\u305a\u3067\uff0c\u591a\u69d8\u306a\u9175\u7d20\u3092\u3064\u304f\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u304b\u3063\u305f\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3053\u306e\u305f\u3081\uff0c\u9175\u7d20\u3068\u57fa\u8cea\u306e\u95a2\u4fc2\u3082\u73fe\u5728\u3068\u6bd4\u3079\u308b\u3068\u304b\u306a\u308a\u5927\u96d1\u628a\u306a\u3082\u306e\u3067\uff0c\u9175\u7d20\u306e\u89e6\u5a92\u3068\u3057\u3066\u306e\u80fd\u529b\u3082\u4f4e\u304b\u3063\u305f\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u305f\u3068\u3048\u3070\u56f3\uff12\u306e\u3088\u3046\u306b\uff0c\u3042\u308b\u9175\u7d20\u306f\u8907\u6570\u7a2e\u985e\u306e\u57fa\u8cea\uff08A\uff5eC\uff09\u3068\u7d50\u5408\u3057\u3066\uff0c\u8907\u6570\u306e\u53cd\u5fdc\u306e\u89e6\u5a92\u3068\u3057\u3066\u6a5f\u80fd\u3057\u305f\u3068\u63a8\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"443\" src=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme2-1024x443.png\" alt=\"\" class=\"wp-image-1801\" srcset=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme2-1024x443.png 1024w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme2-300x130.png 300w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme2-768x332.png 768w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme2-1536x664.png 1536w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme2-2048x886.png 2048w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u521d\u671f\u306e\u751f\u7269\u306e\u9175\u7d20\u306b\u3064\u3044\u3066\u306e\u63a8\u6e2c\u306f\uff0c\u9175\u7d20\u306e\u5316\u77f3\u304c\u6b8b\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u304b\u3089\u4ee5\u524d\u306f\u5358\u306a\u308b\u60f3\u50cf\u306b\u904e\u304e\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\uff0c\u6700\u8fd1\u3067\u306f\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u3092\u6bd4\u8f03\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\uff0c\u904e\u53bb\u306e\u751f\u7269\u304c\u3082\u3063\u3066\u3044\u305f\u7956\u5148\u578b\u306e\u9175\u7d20\u907a\u4f1d\u5b50\u306e\u63a8\u5b9a\u304c\u53ef\u80fd\u306b\u306a\u308a\uff0c\u3055\u3089\u306b\u907a\u4f1d\u5b50\u306eDNA\u914d\u5217\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7acb\u4f53\u69cb\u9020\u3092\u63a8\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u3053\u306e\u65b9\u6cd5\u3067\uff0c\u7956\u5148\u578b\u306e\u9175\u7d20\u3092\u5b9f\u969b\u306b\u5fa9\u5143\u3057\u3066\u89e6\u5a92\u53cd\u5fdc\u3092\u307f\u305f\u3068\u3053\u308d\uff0c\u8907\u6570\u7a2e\u985e\u306e\u57fa\u8cea\u3068\u53cd\u5fdc\u3057\u3066\u3044\u305f\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u305f\u3068\u3044\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u57fa\u8cea\u7279\u7570\u6027\u306e\u7372\u5f97<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9175\u7d20\u306f\uff0c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u57fa\u8cea\u7279\u7570\u6027\u3092\u7372\u5f97\u3057\u3066\u3044\u304f\u306e\u3060\u308d\u3046\u304b\u3002\u3053\u306e\u904e\u7a0b\u306f\uff0c\u56f33\u306e\u3088\u3046\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"581\" src=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme3-1024x581.png\" alt=\"\" class=\"wp-image-1802\" srcset=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme3-1024x581.png 1024w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme3-300x170.png 300w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme3-768x436.png 768w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme3-1536x872.png 1536w, https:\/\/www.hamajima.co.jp\/rika\/bio\/wp-content\/uploads\/2023\/03\/enzyme3-2048x1162.png 2048w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u591a\u304f\u306e\u53cd\u5fdc\u3067\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u9175\u7d20\u304c\u50cd\u304f\u305f\u3081\u306b\u306f\uff0c\u907a\u4f1d\u5b50\u91cd\u8907\uff08<a href=\"#\u6ce81\">\u6ce81<\/a>\uff09\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u305f\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u9175\u7d20\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u907a\u4f1d\u5b50\u304c\u91cd\u8907\u3057\u3066\u5897\u3048\uff0c\u907a\u4f1d\u5b50\u304c\u5909\u5316\u3059\u308b\u3068\uff0c\u6d3b\u6027\u90e8\u4f4d\u306e\u7acb\u4f53\u69cb\u9020\u304c\u7570\u306a\u308b\u9175\u7d20\u304c\u751f\u3058\u308b\u3002\u3053\u308c\u304c\u65b0\u305f\u306a\u57fa\u8cea\u3068\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u3088\u3046\u306b\u306a\u308b\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\uff0c\u9175\u7d20\u304c\u57fa\u8cea\u7279\u7570\u6027\u3092\u7372\u5f97\u3057\u3066\u3044\u304f\u969b\u306b\u306f\uff0c\u89e6\u5a92\u6d3b\u6027\u3082\u5411\u4e0a\u3057\u3066\u3044\u3063\u305f\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u73fe\u5728\u306e\u9175\u7d20\u304c\u6700\u3082\u9ad8\u3044\u89e6\u5a92\u6d3b\u6027\u3092\u3082\u3064\u3068\u306f\u9650\u3089\u306a\u3044<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306b\u8003\u3048\u308b\u3068\uff0c\u751f\u7269\u306e\u9577\u3044\u6b74\u53f2\u306e\u4e2d\u3067\u57fa\u8cea\u7279\u7570\u6027\u3092\u7372\u5f97\u3057\u3066\u89e6\u5a92\u6d3b\u6027\u3092\u5411\u4e0a\u3055\u305b\u3066\u304d\u305f\u306e\u3060\u304b\u3089\uff0c\u73fe\u5728\u306e\u751f\u7269\u304c\u3082\u3063\u3066\u3044\u308b\u9175\u7d20\u306e\u89e6\u5a92\u6d3b\u6027\u306f\u6700\u9ad8\u6c34\u6e96\u306e\u3082\u306e\u3067\u3042\u308d\u3046\u3068\u8003\u3048\u304c\u3061\u3067\u3042\u308b\u304c\uff0c\u5fc5\u305a\u3057\u3082\u305d\u3046\u3068\u306f\u9650\u3089\u306a\u3044\u3002\u7c73\u56fd\u306e\u30d5\u30e9\u30f3\u30b7\u30b9\u30fb\u30a2\u30fc\u30ce\u30eb\u30c9\uff08Frances H. Arnold\uff09\u306f\uff0c\u3042\u308b\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u7a81\u7136\u5909\u7570\uff08<a href=\"#\u6ce82\">\u6ce8\uff12<\/a>\uff09\u3092\u8d77\u3053\u3057\uff0c\u3053\u306e\u7a81\u7136\u5909\u7570\u3057\u305f\u907a\u4f1d\u5b50\u3092\u7d30\u83cc\u3067\u767a\u73fe\u3055\u305b\u305f\u3002\u6b21\u306b\uff0c\u305d\u306e\u4e2d\u304b\u3089\u3082\u3068\u306e\u9175\u7d20\u3088\u308a\u3082\u5927\u304d\u306a\u6d3b\u6027\u3092\u793a\u3059\u9175\u7d20\u3092\u9078\u629e\u3057\uff0c\u518d\u3073\u7a81\u7136\u5909\u7570\u3092\u8d77\u3053\u3059\u3053\u3068\u3092\u7e70\u308a\u8fd4\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u3063\u3066\uff0c\u3082\u3068\u306e\u9175\u7d20\u3088\u308a\u3082250\u500d\u8fd1\u3044\u9175\u7d20\u6d3b\u6027\u3092\u3082\u3064\u9175\u7d20\u304c\u5f97\u3089\u308c\u305f\u3002\u3053\u306e\u624b\u6cd5\u306f\uff0c\u81ea\u7136\u306b\u8d77\u3053\u308b\u9032\u5316\u3092\u4eba\u70ba\u7684\u306b\u8d77\u3053\u3059\u3082\u306e\u3067\u300c\u6307\u5411\u6027\u9032\u5316\u300d\u3068\u3088\u3070\u308c\u3066\u304a\u308a\uff0c\u9032\u5316\u3092\u518d\u73fe\u3059\u308b\u3088\u3046\u306a\u5074\u9762\u3082\u3042\u308b\u3002\u73fe\u5728\u3053\u306e\u624b\u6cd5\u306f\uff0c\u30d0\u30a4\u30aa\u71c3\u6599\u3084\u533b\u85ac\u54c1\u306a\u3069\u306e\u88fd\u9020\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b\u30022018\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9032\u5316\u5206\u5b50\u5de5\u5b66\u5206\u91ce\u306e\u7814\u7a76\u8005\u306b\u8d08\u3089\u308c\uff0c\u30a2\u30fc\u30ce\u30eb\u30c9\u3082\u4ed6\u306e2\u4eba\u306e\u7814\u7a76\u8005\u3068\u3068\u3082\u306b\u53d7\u8cde\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6ce8<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"\u6ce81\">\u6ce81\uff1a\u907a\u4f1d\u5b50\u91cd\u8907<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u304c\u3064\u304f\u3089\u308c\u308b\u3053\u3068\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"\u6ce82\">\u6ce82\uff1a\u7a81\u7136\u5909\u7570<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">DNA\u3084\u67d3\u8272\u4f53\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e80\u8c37\u5c06\u53f2\uff0e\u9006\u9032\u5316\u306f\u201cspecialist\u201d\u306e\u58c1\u3092\u7834\u308b\u304b\uff1f\u2015\u9175\u7d20\u5de5\u5b66\u306e\u8996\u70b9\u304b\u3089\u2015\uff0e\u751f\u7269\u5de5\u5b66\u4f1a\u8a8c\uff0c92(5), 238\u2013342\uff0e2016<\/li>\n\n\n\n<li>Taryn L. O&#8217;Loughlin, Wayne M. Patrick, Ichiro Matsumura, Natural history as a predictor of protein evolvability, Protein Engineering, Design and Selection, Volume 19, Issue 10, October 2006, Pages 439\u2013442<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u3010\u53c2\u8003\u30a6\u30a7\u30d6\u3011<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u201cThe Nobel Prize in Chemistry 2018\u201d Nobel Prize organisation\uff0c<a href=\"https:\/\/www.nobelprize.org\/prizes\/chemistry\/2018\/summary\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nobelprize.org\/prizes\/chemistry\/2018\/summary\/<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u8cea\u7279\u7570\u6027\u306e\u7372\u5f97 \u9175\u7d20\u306e\u57fa\u8cea\u7279\u7570\u6027 \u57fa\u8cea\u7279\u7570\u6027\u3068\u306f\u300c\u9175\u7d20\u306f\u7279\u5b9a\u306e\u57fa\u8cea\u3068\u3057\u304b\u53cd\u5fdc\u3057\u306a\u3044\u300d\u3068\u3044\u3046\u3053\u3068\u3067\uff0c\u9175\u7d20\u3068\u57fa\u8cea\u306f\u300c\u304b\u304e\u3068\u304b\u304e\u7a74\u306e\u95a2\u4fc2\u300d\u306b\u305f\u3068\u3048\u3089\u308c\u308b\u3002\u9175\u7d20\u306f\u6d3b\u6027\u90e8\u4f4d\u3068\u3088\u3070\u308c\u308b\u90e8\u5206\u3067\u57fa\u8cea\u3068\u7d50\u5408\u3057\u3066\uff0c\u9175\u7d20-\u57fa\u8cea\u8907\u5408\u4f53\u3092\u3064\u304f\u3063 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.hamajima.co.jp\/rika\/bio\/substratespecificity\/\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;\u3010\u9032\u5316View\u3011\u57fa\u8cea\u7279\u7570\u6027\u306e\u7372\u5f97&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-2357","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - 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